Adipokines and insulin action
نویسندگان
چکیده
منابع مشابه
Adipokines and insulin resistance.
Obesity is associated with an array of health problems in adult and pediatric populations. Understanding the pathogenesis of obesity and its metabolic sequelae has advanced rapidly over the past decades. Adipose tissue represents an active endocrine organ that, in addition to regulating fat mass and nutrient homeostasis, releases a large number of bioactive mediators (adipokines) that signal to...
متن کاملAdipokines and Hepatic Insulin Resistance
Obesity is a major risk factor for insulin resistance and type 2 diabetes. Adipose tissue is now considered to be an active endocrine organ that secretes various adipokines such as adiponectin, leptin, resistin, tumour necrosis factor-α, and interleukin-6. Recent studies have shown that these factors might provide a molecular link between increased adiposity and impaired insulin sensitivity. Si...
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OBJECTIVES We evaluated the hypothesis that plasma levels of adiponectin and leptin are independently but oppositely associated with coronary artery calcification (CAC), a measure of subclinical atherosclerosis. In addition, we assessed which biomarkers of adiposity and insulin resistance are the strongest predictors of CAC beyond traditional risk factors, metabolic syndrome, and plasma C-react...
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For many years, adipose tissue was considered as an inert energy storage organ that accumulates and stores triacylglycerols during energy excess and releases fatty acids in times of systemic energy need. However, over the last two decades adipose tissue depots have been established as highly active endocrine and metabolically important organs that modulate energy expenditure and glucose homeost...
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Corresponding author: Jee-Young Oh Department of Internal Medicine, Ewha Womans University Mokdong Hospital, 1071 Anyangcheon-ro, Yangcheon-gu, Seoul 158-710, Korea E-mail: [email protected] The prevalence of obesity is rapidly increasing worldwide, and obesity is a well-known risk factor for type 2 diabetes involving insulin resistance. In recent decades, marked environmental and lifestyle chang...
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ژورنال
عنوان ژورنال: Adipocyte
سال: 2014
ISSN: 2162-3945,2162-397X
DOI: 10.4161/adip.27552